Appleton (Menominee: Ahkōnemeh) is a city in and the county seat of Outagamie County, Wisconsin, United States. A small portion of the city also extends into Calumet and Winnebago counties. It is situated on the Fox River, 30 miles (48 km) southwest of Green Bay and 100 miles (160 km) north of Milwaukee. As of the 2020 census, it had a population of 75,644, making it the sixth-most populous city in Wisconsin. Appleton is part of the Fox Cities metropolitan area, the third-largest metro area in the state with over 415,000 residents. Appleton serves as the heart of the Fox River Valley, which is home to Lawrence University, the Fox Cities Exhibition Center, Fox Cities Performing Arts Center, Fox River Mall, Neuroscience Group Field at Fox Cities Stadium, Appleton International Airport, and the Valley's two major hospitals: St. Elizabeth Hospital and ThedaCare Regional Medical Center–Appleton. It also hosts regional events such as Octoberfest and the Mile of Music.