Las Cruces (; Spanish: [las 'kruses]; lit. 'the crosses') is a city in Doña Ana County, New Mexico, United States, and its county seat. The population was 111,385 at the 2020 census, making it the second-most populous city in New Mexico, and the largest in both Doña Ana County and southern New Mexico. It is the principal city of the Las Cruces metropolitan statistical area, which encompasses all of Doña Ana County and had an estimated 230,000 residents in 2024. The city is also part of the larger El Paso–Las Cruces combined statistical area. Las Cruces is the economic and geographic center of the Mesilla Valley, the agricultural region on the floodplain of the Rio Grande, which extends from Radium Springs to the west side of El Paso, Texas. The Organ Mountains, 10 miles (16 km) to the east, are dominant in the city's landscape, along with the Doña Ana Mountains, Robledo Mountains, and Picacho Peak. Las Cruces lies 225 mi (362 km) south of Albuquerque, 42 mi (68 km) northwest of El Paso, and 41 mi (66 km) north of the Mexico–United States border. The city's major employer is the federal government at nearby White Sands Test Facility and White Sands Missile Range. Spaceport America, which has corporate offices in Las Cruces, operates from 55 mi (89 km) to the north; it has completed several successful crewed, suborbital flights. The city is also the headquarters for Virgin Galactic, the world's first company to offer suborbital spaceflights. Las Cruces is the home of New Mexico State University, New Mexico's only land-grant university.