Maryland (US: MERR-il-ənd) is a state in the Mid-Atlantic region of the United States. It borders Virginia to its south, West Virginia to its west, Pennsylvania to its north, Delaware and the Atlantic Ocean to its east, and the national capital of Washington, D.C. to the southwest. With a total area of 12,407 square miles (32,130 km2), Maryland is the ninth-smallest state by land area, and its population of 6,177,224 ranks it the 19th-most populous state and the fifth-most densely populated. Maryland's capital is Annapolis, and the most populous city is Baltimore. Maryland's coastline was first explored by Europeans in the 16th century. Prior to that, it was inhabited by several Native American tribes, mostly the Algonquian peoples. As one of the original Thirteen Colonies, Maryland was founded by George Calvert, 1st Baron Baltimore, a Catholic convert who sought to provide a religious haven for Catholics persecuted in England. In 1632, Charles I of England granted Lord Baltimore a colonial charter, naming the colony after his wife, Henrietta Maria. In 1649, the Maryland General Assembly passed an Act Concerning Religion, which enshrined the principle of toleration. Religious strife was common in Maryland's early years, and Catholics remained a minority, albeit in greater numbers than in any other English colony. Maryland's early settlements and population centers clustered around waterways that empty into the Chesapeake Bay. Its economy was heavily plantation-based and centered mostly on the cultivation of tobacco. Demand for cheap labor from Maryland colonists led to the importation of numerous indentured servants and enslaved Africans. In 1760, Maryland's current boundaries took form following the settlement of a long-running border dispute with Pennsylvania. Many of its citizens played key political and military roles in the American Revolutionary War. Although it was a slave state, Maryland remained in the Union during the American Civil War, and its proximity to Washington D.C. and Virginia made it a significant strategic location. After the Civil War ended, Maryland took part in the Industrial Revolution, driven by its seaports, railroad networks, and mass immigration from Europe. Since the 1940s, the state's population has grown rapidly, to approximately six million residents, and it is among the most densely populated U.S. states. As of 2015, Maryland had the highest median household income of any state, owing in large part to its proximity to Washington, D.C., and a highly diversified economy spanning manufacturing, retail services, public administration, real estate, higher education, information technology, defense contracting, health care, and biotechnology. Maryland is one of the most multicultural states in the country; it is one of the six states where non-Whites compose a majority of the population, with the fifth-highest percentage of African Americans, and high numbers of residents born in Africa, Asia, Central America, and the Caribbean. The state's central role in U.S. history is reflected by its hosting of some of the highest numbers of historic landmarks per capita. The western portion of the state contains stretches of the Appalachian Mountains, the central portion is primarily composed of the Piedmont, and the eastern side of the state makes up a significant portion of Chesapeake Bay. Sixteen of Maryland's twenty-three counties, and the city of Baltimore, border the tidal waters of the Chesapeake Bay estuary and its many tributaries, which combined total more than 4,000 miles of shoreline. Although one of the smallest states in the U.S., it features a variety of climates and topographical features that have earned it the moniker of America in Miniature. In a similar vein, Maryland's geography, culture, and history combine elements of the Mid-Atlantic, Northeastern, and Southern regions of the country.