Baton Rouge ( BAT-ən ROOZH; French: Bâton-Rouge, pronounced [bɑtɔ̃ ʁuʒ]; Louisiana Creole: Batonrouj) is the capital city of the U.S. state of Louisiana. Located on the eastern bank of the Mississippi River, it had a population of 227,470 as of 2020; it is the seat of Louisiana's most populous parish (county-equivalent), East Baton Rouge Parish, and the center of Louisiana's second-largest metropolitan area and city, Greater Baton Rouge. The Baton Rouge area owes its historical importance to its strategic site upon the Istrouma Bluff, the first natural bluff upriver from the Mississippi River Delta at the Gulf of Mexico. This allowed development of a business quarter safe from seasonal flooding. In addition, it built a levee system stretching from the bluff southward to protect the riverfront and low-lying agricultural areas. Baton Rouge has developed as a culturally rich center, with settlement by immigrants from numerous European nations and African peoples brought to North America as slaves or indentured servants. It was ruled by seven different nations: the French, Spanish and British in the colonial era; briefly the Republic of West Florida; the United States as a territory and a state; the Confederate States of America; and the United States again since the end of the American Civil War. Throughout the governance of these various occupying national governments of Baton Rouge, the city and its metropolitan area have developed as a multicultural region practicing many religious traditions from Catholicism to Protestantism and Louisiana Voodoo. Baton Rouge is a major, growing industrial, petrochemical, medical, research, motion picture, and technology center of the American South. It is the location of Louisiana State University—the LSU system's flagship university and the state's largest institution of higher education. It is also the location of Southern University, the flagship institution of the Southern University System—the nation's only historically black college system. The Port of Greater Baton Rouge is the tenth-largest in the U.S. by tonnage shipped, and it is the farthest upstream Mississippi River port capable of handling Panamax ships. Major corporations participating in the Baton Rouge metropolitan statistical area's economy include Amazon, Lamar Advertising Company, BBQGuys, Marucci Sports, Piccadilly Restaurants, Raising Cane's Chicken Fingers, ExxonMobil, Brown & Root, Shell, and Dow Chemical Company.