Indiana ( IN-dee-AN-ə) is a state in the Midwestern region of the United States. It borders Lake Michigan to the northwest, Michigan to the north and northeast, Ohio to the east, the Ohio River and Kentucky to the south and southeast, and the Wabash River and Illinois to the west. Nicknamed "the Hoosier State", Indiana is the 38th-largest by area and the 17th-most populous of the 50 states. Its capital and largest city is Indianapolis. Indiana was admitted to the Union as the 19th state on December 11, 1816. Various indigenous peoples inhabited what would become Indiana for thousands of years, some of whom the U.S. government expelled between 1800 and 1836. Indiana received its name because the state was largely possessed by native tribes even after it was granted statehood. Since then, settlement patterns in Indiana have reflected regional cultural segmentation present in the Eastern United States; the state's northernmost tier was settled primarily by people from New England and New York, Central Indiana by migrants from the Mid-Atlantic states and adjacent Ohio, and Southern Indiana by settlers from the Upland South, particularly Kentucky and Tennessee. Indiana has a diverse economy with a gross state product of $352.62 billion in 2021. It has several metropolitan areas with populations greater than 100,000 and a number of smaller cities and towns. Indiana is home to professional sports teams, including the NFL's Indianapolis Colts and the NBA's Indiana Pacers. The state also hosts several notable competitive events, such as the Indianapolis 500, held at Indianapolis Motor Speedway.